VENTRAL FOREBRAIN - keywords
ventral forebrain
imaging
libro
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IQ
preterm “C"
nuclei
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disorders
consciousness
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Garcia-Alix et al. 2015
>
development
anatomy
adults ex preterm versus control
Grothe et al. 2017
ventral forebrain
Lagercrantz 2025
arousal
ventral forebrain references
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Do AD, Portet C, Goutagny R, Jackson J. The claustrum and synchronized brain states. Trends Neurosci. 2024 Dec;47(12):1028-1040.
Garcia-Alix A, Arnaez J, Agut T (2014) Neonatal neurology at a glance. Ediciones San Juan de dios.
Gloor P (1997) The temporal lobe and limbic system. Oxford University press.
Grothe MJ, Scheef L, Bäuml J, Meng C, Daamen M, Baumann N, Zimmer C, Teipel S, Bartmann P, Boecker H, Hudson AJ (2009) Consciousness: physiological dependence on rapid memory access. Frontiers in Bioscience 14, 2779-2800
Wolke D, Wohlschläger A, Sorg C. Reduced Cholinergic Basal Forebrain Integrity Links Neonatal Complications and Adult Cognitive Deficits After Premature Birth. Biol Psychiatry. 2017 Jul 15;82(2):119-126.
Lagercrantz H, Changeux J-P (2009) The emergence of human consciousness: from fetal to neonatal life. Pediatric Research 65; no 3; 255-260.
Lagercrantz H (2025) The Awakening of the Newborn Human Infant and the Emergence of Consciousness. Acta Paediatr, 114: 823-828.
Leon-Dominguez U, Leon-Carrion J (2019) A neurofunctional model of consciousness: its neurophysiological and cognitive bases. Rev Neurol 16;69(4):159-166.
ten Donkelaar HJ (2011) Clinical neuroanatomy. Brain circuitry and its disorders. Springer.
nu. basalis ‘Meynert’(cholinergic to neocortex: attention focus); macrocellular basal forebrain
nu. of the diagonal band
ventral pallidum and nu. accumbens septi (cholinergic to hippocampus, memory)
medial septal nuclei (agression, reward)
extended amygdala = substantia innominata, between BNST and amygdala
the nuclei of the ventral forebrain
loops
cortico-cortical loops are not alone in activating cortical areas; activation from thalamus and brainstem are concurrent
amygdala
- per neocortical column
(Lorento de No 1933, Montcastle 1957)
80-100 neurons
- from cortical layer 4 to layer 1 the ascending dendrites converge and produce an appearance of increased packing density
- dendritic bundling organised around thalamo-cortical axons
- column diameter around 50 µm
- dendrite bundle of local circuit neurons generate theta (4-8Hz) and gamma (30-100 Hz) oscillations
- dendrodendritic synapses and gap junctions essential for fast computation
are tonically graded in this network, not action potential mediated
- adjacent modules of associational or commissural nature have limited overlap, but there is local cross-talk, over distances of up to 3 mm
- columns (modules) are in register with other colums all over the isocortex, reciprocally; such cortico-cortical loops subserve as specific aspect of information processing (fMRI)
components
claustrum
µcolumns
not selective activation of the cortical network by cholinergic Ch 1-4 fibres but a global modulating action, independent of specific cortical areas and layers --> increase of signal to noise ratio
——> highest ACh release from cholinergic nuclei at ponto-mesencephalic junction (Ch 5 and 6) is during the wakeful alert state and REM sleep (gamma activity, desynchronisation of the EEG)
axons
ACh
GABA
adenosine
Ch1-7
receptors
fish
modulation
NT/NM
ARAS
the entire pallium and subpallium is in fact extreme specialisation of the alar domain of the first neuromere = the hypothalamus
the ventral forebrain is part of the subpallium; more specifically an initial diagonal band between the preoptic area and pallidum, extending between septum and amygdala
the connection between the linked deep grey nuclei and the brainstem is within the medial forebrain bundle
(sub)pallium
MFB
text
neuromeres
aging
ventral forebrain anatomy
efferents rat
thyroid
perforata
efferents human
>
epilepsy
function
caudal
rostral
two paths
afferents
septal nu.
insula
L-R
ventral striatum
PMA 31 w
PMA 23 w
AComm
AC conn.
arteries
MRI
veins
PMA 36 w
ventral forebrain imaging in vivo
cribrosa
clot v3
basal vv
sup. striate vv
GBS
ventral forebrain disorders
arachnoid
viscosity
stafylo
HLH
Mac OS X 2Û
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